Alexander Fleming House was a multi-storey office building designed by Hungarian-born architect Ernö Goldfinger and constructed in the early 1960s to be the headquarters of the Department of Health and Social Security.

It is located on Newington Causeway on the east side of the busy Elephant and Castle junction in the London Borough of Southwark in south-east London.

The building, some 55 m tall at its highest point, became notorious for sick building syndrome and the DHSS civil servants were eventually moved out. After sitting empty for some years, the building was eventually converted to residential use in 1998, and renamed "Metro Central Heights".