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Listed below are the 15 occurrences of Major League Baseball players who have hit four home runs in a single game.
Notes
- Lowe, Gehrig, Colavito, Schmidt, Cameron and Delgado hit each of their four home runs in consecutive at-bat.
- Klein, Seerey and Schmidt each needed extra innings to get four home runs.
- Delahanty hit all inside-the-park.
| Date | Player | Team
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| May 30, 1894 | Bobby Lowe | Boston Beaneaters, NL
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| July 13, 1896 | Ed Delahanty | Philadelphia Phillies, NL
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| June 3, 1932 | Lou Gehrig | New York Yankees, AL
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| July 10, 1936 | Chuck Klein | Philadelphia Phillies, NL
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| July 18, 1948 | Pat Seerey | Chicago White Sox, AL
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| August 31, 1950 | Gil Hodges | Brooklyn Dodgers, NL
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| July 31, 1954 | Joe Adcock | Milwaukee Braves, NL
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| June 10, 1959 | Rocky Colavito | Cleveland Indians, AL
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| April 30, 1961 | Willie Mays | San Francisco Giants, NL
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| April 17, 1976 | Mike Schmidt | Philadelphia Phillies, NL
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| July 6, 1986 | Bob Horner | Atlanta Braves, NL
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| August 7, 1993 | Mark Whiten | St. Louis Cardinals, NL
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| May 2, 2002 | Mike Cameron | Seattle Mariners, AL
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| May 23, 2002 | Shawn Green | Los Angeles Dodgers, NL
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| September 25, 2003 | Carlos Delgado | Toronto Blue Jays, AL
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