Clodius is the Roman nomen Claudius altered to a spelling that would have sounded plebeian to Roman ears. The original alteration was a political maneuver by P. Clodius Pulcher.

• Publius Clodius Pulcher, Republican politician
• Clodia, second sister of Publius Clodius
• Clodius Aesopus, tragedian 50s BC
• Caius Clodius Vestalis, possible builder of Via Clodia
• Publius Clodius Thrasea Paetus, senator during Nero
• Lucius Clodius Macer, legatus who revolted against Nero
• Publius Clodius Quirinalis, from Arelate in Gaul, teacher of rhetoric in time of Nero
• Decimus Clodius Albinus, rival emperor 196-197
• Marcus Clodius Pupienus Maximus co-emperor 238

Clodio the Longhair, a chieftain of the Salian Franks, is sometime called "Clodius I".