Cr mimetic - Definition and Overview

A CR (Calorie Restriction) mimetic is a particular compound or molecule that may -- if successful -- enable organisms to derive many of the health and life-extending benefits noted in calorically restricted diets. If an efficacious CR mimetic is developed, it may allow an organism to feed ad libitum and (simultaneously) achieve a long lifespan. The efficacy of such compounds might, upon safe and successful testing in animal subjects, pave the way for substantial increases in human lifespan.

Candidate compounds include:

• Resveratrol is found in red wine and grapes. Many supplement companies market inexpensive concentrates.
• metformin mimics the gene expression of CR mice, and has extended mice's maximum life spans. It is already clinically approved to treat diabetes.
• R-Lipoic Acid
• 2-deoxy-D-glucose, or 2-DG. 2-DG interferes in glycolysis, starving a cell of fuel.
• Iodoacetate

External Links: A List of Potential CR Mimetics (http://www.crmimetics.com) R-Lipoic Acid: A Possible Anti-Aging Intervention (http://www.r-lipoic.com)