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DNA polymerase III holoenzyme or Pol III is a holoenzyme that aids in DNA replication.
Components:
- 2 DNA Pol III enzymes, made up of α, ε, θ subunits.
- 2 β units which act as sliding DNA clamps.
- 2 τ units which connect the clamp loader to the 2 DNA Pol III enzymes.
- 1 γ unit which acts as a clamp loader for the lagging strand Okazaki fragments. The γ units is made up of 3 γ subunits.
DNA Polymerase III can quickly conduct 5' to 3' replication. It can also back up to fix errors - "editing" by 3' to 5' exonuclease activity.
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