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Eduardo Kac was the first person to have a microchip implanted in his body. He did this as a form of social commentary, in that it causes us to think deeply about the relationship we hold with technology. He put the microchip in the lower part of his leg, on his calf.
When he was at Telematic Connections (http://telematic.walkerart.org/telereal/) (where his work was on exhibit) he'd mentioned the reason he chose this spot on his body was that that is where slaves were often branded. The work he had on exhibit was entitled Teleporting an Unknown State.
Another famous work of his is the experiment GFP Bunny in which he created a green-fluorescent rabbit by implanting a gene from a type of jellyfish inside it.
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