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Eppes may refer to several American people:
- Francis Eppes
- John Wayles Eppes -- Democrat; U.S. Representative from Virginia; U.S. Senator from Virginia
- Nelda Eppes -- Republican; Presidential Elector for Texas
- Richard Eppes -- surgeon
- T. J. Eppes -- Democrat; Delegate to Democratic National Convention from Florida
- Eppes is also a commune in the Aisne département
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