Isabel Jewell (July 19, 1907 - April 5, 1972) was an American film actress.

Born in Shoshone, Wyoming, Jewell was a Broadway actress who achieved immediate success and glowing critical reviews in two productions, Up Pops the Devil (1930) and Blessed Event (1932). She was brought to Hollywood for the film version of the latter, by Warner Brothers. A petite 4' 11" tall and with platinum blonde hair, Jewell appeared in a variety of supporting roles during the early 1930s. She played stereotypical gangster's women in such films as Manhattan Melodrama (1934) and Marked Woman (1937). She was well received playing against type, as a seamstress sentenced to death on the guillotine, in A Tale of Two Cities (1935). Her most significant role was as the prostitute Gloria Stone in Lost Horizon (1937).

Her subsequent films included Gone With the Wind (1939), Northwest Passage (1940), and High Sierra (1941), but by the end of the 1940s her roles had reduced in significance to the degree that her performances were often uncredited. By the end of her career she had appeared in more than one hundred films.

She died in Hollywood, California.

Isabel Jewell has a star on the Hollywood Walk of Fame for her contribution to Motion Pictures, at 1560 Vine St.