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Karyorrhexis is the fragmentation of the nucleus of a cell undergoing programmed cell death (see Naoufal Zamzami and Guido Kroemer: "Apoptosis: Condensed matter in cell death", Nature Vol. 401 p. 127, 09 Sep. 1999 [1] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10490018)).
It is usually preceded by pyknosis (clumping and condensation of chromatin in the nucleus).
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