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The kinetochore is the protein structure which assembles on the centromere and links the chromosome to the mitotic spindle during mitosis.The kinetochore contains two regions: an inner kinetochore, which is tightly associated with the centromere DNA; and an outer kinetochore, which interacts with microtubules. Even the simplest kinetochores consist of more than 25 different proteins.
Certain proteins in the kinetochore attach it to the microtubules of the mitotic spindle. There are also motor proteins, including both dynein and kinesin, which generate forces that move chromosomes during mitosis. Other proteins monitor the microtubule attachment as well as the tension between sister kinetochores and activate the spindle checkpoint when either of these is absent.
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