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The initials LSD can have several meanings:
- LSD is the hallucinogenic drug D-Lysergic Acid Diethylamide, also known as "acid". LSD is an acronym of the German name for the compound, Lyserg-Säure-Diäthylamid.
- LSD is the US Navy hull classification symbol for Dock Landing Ship.
- LSD in numerical analysis is an abbreviation for Least Significant Digit, see Loss of significance.
- LSD stands for limited slip differential in automobile engineering.
- LSD or £sd, for Librae, Solidi, Denarii (pounds, shillings, pence) was the popular name for the pre-decimal currencies of the United Kingdom and several other countries.
- LSD at Harvey Mudd College is the unofficial name of a class in the computer science major, "Software Development," which before 1991, was called "Largescale Software Development." Puns revolve around both taking and dropping the class.
- LSD is not to be confused with LDS, the Latter Day Saints movement.
- The French rock and roll band La Sourie Deglinguee is sometimes called LSD.
- Line Sharing Device.
- Chicago's Lake Shore Drive.
- Long Shore Drift.
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