This is a list of some famous people from South Carolina.
- Mary McLeod Bethune, 1875 - 1955 from Mayesville, South Carolina founder of Bethune-Cookman College, advisor to Presidents Hoover, Roosevelt, Truman and Eisenhower
- John Caldwell Calhoun (1782–1850), Senator, Secretary of State, Secretary of War, and the seventh Vice President of the US.
- Kevin Garnett (1976-), NBA star, NBA Most Valuable Player in 2004
- Dizzy Gillespie (1917-1993), African-American jazz trumpeter, bandleader, singer and composer from Cheraw, South Carolina
- Ronald McNair (1950 - 1986) astronaut killed in the explosion of the Space Shuttle Challenger from Lake City, South Carolina
- Robert Mills (1781 - 1855) from Charleston, South Carolina, American architect, designed the Washington monument and many public buildings
- Darius Rucker (1966-), musician, frontman of Hootie & The Blowfish
- Strom Thurmond (1902-2003), politician
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