The Locus ceruleus, also spelled locus coeruleus, (Latin for 'the blue bit') is a nucleus in the brain stem apparently responsible for the physiological reactions involved in stress and panic. This nucleus is the major location of neurons that release norepinephrine throughout the brain.
The locus ceruleus is widely studied in relation to clinical depression, panic disorder and anxiety. Some antidepressant medications including Reboxetine, Venlafaxine and Bupropion as well as ADHD medication Atomoxetine are believed to act on neurons in this area. This area of the brain is also intimately involved in REM sleep.
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