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Methydopa (brand names Aldomet, Apo-Methyldopa, Dopamet, Novomedopa) is a centrally-acting antiadrenergic antihypertensive medication.
When introduced it was a mainstay of antihypertensive therapy, but its use has declined, with increased use of other classes of agents.
Methyldopa is approximately 50% absorbed; it is metabolized in the intestines and liver; its metabolite alpha-methylnorepineprine acts in the brain to stimulate alpha-adrenergic receptors decreasing total peripheral resistance. It is excreted by urine.
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