Necrosis Necrosis

Necrosis - Definition and Overview

Related Words: Ague, Anemia, Ankylosis, Anoxia, Apnea, Asphyxiation, Asthma, Ataxia, Atrophy, Bleeding, Cachexia, Caries, Carrion, Chill, Chills, Colic, Constipation, Convulsion, Coughing, Cyanosis, Decay, Decomposition, Diarrhea

Necrosis (in Greek Νεκρός = Dead) is the name given to unprogrammed death of cells/living tissue (compare with apoptosis - programmed cell death). There are many causes of necrosis including injury, infection, cancer, infarction, inflammation and so on.

There are four distinctive morphologic patterns of necrosis:

  • Coagulative necrosis - typically seen in hypoxic environments. Cell outlines remain after cell death and can be observed by light microscopy (e.g. myocardial infarction, infarct of the spleen)
  • Liquefactive necrosis - is associated with cellular destruction and pus formation (e.g. pneumonia)
  • Caseous necrosis - is a mix of coagulative necrosis and liquefactive necrosis (e.g. tuberculosis)
  • Fatty necrosis - results from the action of lipases on fatty tissues (e.g. acute pancreatitis)
  • Fibrinoid necrosis -

See also

Example Usage of Necrosis

APSFA: Lupus-like syndrome attributable to anti-tumor Necrosis factor alpha therapy in 14 pts during an 8 yr period @ Mayo. http://bit.ly/5yepBl
dctrials: cp-690,550 vs placebo in rheumatoid arthritis ppl on backgrnd methotrex8 w/ inadequ8 response 2 tumor Necrosis factor http://bit.ly/7hZToY
wuwutek: i deliver Necrosis - Necrosis is the humbled slingshot shooter. deathlist: 1. Pb-err annoyance 2. the teapot... http://tumblr.com/xah46r3tc
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