Neostigmine Neostigmine

Neostigmine - Definition

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Neostigmine chemical structure
Neostigmine

(m-hydroxyphenyl)trimethyl-, dimethylcarbamate(ester) ammonium
CAS number
59-99-4
ATC code
N07AA01, S01EB06
Chemical formula C12H19N2O2
Molecular weight 223.294
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Neostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. By interfering with the breakdown of acetylcholine, neostigmine indirectly stimulates both nicotinic and muscarinic receptors.

Clinical Uses

It is used to improve muscle tone in people with Myasthenia gravis and to treat urinary retention resulting from general anaesthetic. It can be used to treat curariform drug toxicity.

Neostigmine is available under several trade names such as Prostigmin (ICN).

Sources

  • Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
  • Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

Example Usage of Neostigmine

usclinicaltrial: intranasal administration of Neostigmine & glycopyrrol8 4 bowel evacuation http://bit.ly/7eNUWZ
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