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 Origin of replication - Definition 

The origin of replication (also called replication origin or oriC) is a unique DNA sequence at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.

The origin of replication a 250 bp sequence rich in adenine-thymine base pairs, which are more easily separated than cytosine-guanine base pairs. It consists of an L box, an M box, and an R box.

The origin of replication binds the pre-replication complex. Specifically, the R box binds dnaA.

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