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Osteosarcoma is the most common primary malignant bone tumour, excluding myeloma and lymphoma. There is a predilection for the metaphyseal region of tubular long bones. 50% of cases occur around the knee.
Prevalence
It accounts for 5% of childhood tumors. It has a bimodal distribution, with 75% occurring in patients below the age of 20. A second peak in incidence occurs in the elderly, usually associated with an underlying bone pathology such as Paget's disease, medullary infarct, or prior irradiation.
Symptoms
Signs
Treatment
Standard therapy is a combination of surgery and chemotherapy.
Prognosis
Canine Osteosarcoma
Osteosarcoma also occurs in dogs and typically afflicts middle aged dogs with long limbs (for example, Greyhounds and German Shepherds). One key difference between osteosarcoma in dogs and humans is that the cancer is far more likely to spread to the lungs in dogs.
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