Phenothiazine Phenothiazine

Phenothiazine - Definition and Overview

Phenothiazines are the largest of the 5 main classes of antipsychotic drugs. Although these drugs are generally effective, there are often serious side-effects including Parkinsonism and sedation (especially in the early stages of treatment).

There are three groups of phenothiazines, differing by their chemical structure and their pharmacological effects: -

Group Autonomic Example Sedative Extrapyramidal side-effect
Aliphatic compounds
moderate Chlorpromazine(Thorazine, Largactil) strong moderate
Promazine moderate moderate
Triflupromazine (Vesprin) strong moderate/strong
Methotrimeprazine (Nozinan)
Piperidines strong Mesoridazine strong weak
Thioridazine (Mellaril) strong weak
Piperazines weak Fluphenazine weak/moderate strong
Perphenazine weak/moderate strong
Prochlorperazine (Stemetil)
Trifluoperazine (Stelazine) moderate strong
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