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Pholoe may signify:
- Pholoe, the place belonging to the Centaur Pholos, where Heracles was entertained as a guest, battled hostile centaurs and killed a brigand Sauros, on his way to find the Erymanthian Boar.
- Pholoe, a genus of Annelid worms, belonging to the Pholoidae, a group of species that is part of the Polychaetes family.
- Pholoe Johnston
- Pholoe tecta a species that is founded in the Bay of Fundy
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