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Phosphofructokinase (PFK) is the most important regulatory enzyme (EC 2.7.1.105) of glycolysis. It is an allosteric enzyme made of 4 subunits and controlled by several activators and inhibitors. This leads to a precise control of glucose and the other monosaccharides galactose and fructose going down the glycolysis pathway.
PFK converts fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ADP. The enzyme has two sites with different affinities for ATP which is both a substrate and an inhibitor.
See also:
- PFK2 (converts fructose 6-phosphate to fructose 2,6-bisphosphate)
- PFP (reversibly interconverts fructose 6-phosphate and fructose 1,6-bisphosphate using inorganic pyrophosphate (rather than ATP)
- fructose bisphosphatase (hydrolyses fructose 1,6-bisphosphate to fructose 6-phosphate)
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