Phospholipase Phospholipase

Phospholipase - Definition and Overview

A phospholipase is an enzyme that converts phospholipids into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D.

Phospholipase A (PLA)

Phospholipase A2
Phospholipase A2 catalyses the first step in the formation of arachidonic acid, the precursor of all eicosanoids (leukotrienes, prostaglandins).

The PDB code for phospolipase A2 is 1CJY (http://www.rcsb.org/pdb/cgi/explore.cgi?pid=258171034362047&page=20&pdbId=1CJY); the EC code is EC 3.1.1.4.

Phospholipase B (PLB)

To be written

Phospholipase C (PLC)

To be expanded

(Bacillus Cereus: PDB 1AH7 (http://www.rcsb.org/pdb/cgi/explore.cgi?pid=266091034362355&page=0&pdbId=1AH7), EC 3.1.4.3) Phospholipase C is a key enzyme in phosphatidylinositol (PI) metabolism. It is activated by either G proteins (making it part of a G protein-coupled receptor signal transduction pathway) or by transmembrane receptors with intrinsic or associated tyrosine kinase activity. It converts phosphatidylinositol to either inositol triphosphate or diacylglycerol.

Example Usage of Phospholipase
Sciencia: Rapid activation of specific Phospholipase(s) D by cytokinin in Amaranthus assay system http://kele.es/mDV
WandaMoosejaw: "Phospholipase C (PLC) hydrolyzes phospholipids - specifically phosphatidylinositol-4,5-bi..." nothing is sticking to my brain anymore, UGH!
healthtopicsaz: Cerebrospinal Fluid Secretory Ca2+-Dependent Phospholipase A2 Activity Is Increased in Alzheimer Disease [Pro... http://tinyurl.com/ygkuuah
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