Pier Luigi Farnese is also the name of Pier Luigi Farnese (b. 1435), father of Pope Paul III.

Pier Luigi Farnese was born in 1503, the illegitimate son of Cardinal Alessandro Farnese (cardinal). He became a soldier and participated in the sack of Rome in 1527.

When his father was elevated to the papacy, as Paul III, in 1534, Pier Luigi was named Captain-General of the Church. His father later made him Duke of Parma and Piacenza, properties that had previously been a part of the Holy See. He ruled these cities tyranically, and the aristocracy of Piacenza murdered him in 1547.