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The Plague of Justinian is the first known pandemic on record, and it also marks the first recorded case of bubonic plague. The plague occurred in around CE 550; it started in Africa and moved northward until it reached Constantinople (formerly known as Byzantium).
The Byzantine historian Procopius records that, at its peak, the plague was killing 10,000 people in Constantinople every day. The Byzantine Emperor Justinian ensured that new legislation was swiftly enacted so as to deal more efficiently with the glut of inheritance suits being brought as a result of the plague deaths (Moorhead, J., Justinian, London 1994).
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Example Usage of Justinian
drsanti24601: My Hagia Sophia will be better than Emperor Justinian's!
Buddy_Dharma: Leading an early game war against Justinian as Geoge W(ashington) in Civ IV. That game never gets old...
latikambourke: Aw. Thanks so much Justinian. X RT @JustinianNews: @latikambourke I loved your five mins at #Media140. I wish you'd spoken for 20