Plautia Urgulanilla (lived first century) was the first wife of the future emperor Claudius. They married around AD 15, but he divorced her nine years later on grounds of adultery and suspicion of murder.

She gave birth to a son, Claudius Drusus, and a daughter, Claudia, who was later repudiated by Claudius.

Her father was Marcus Plautius Silvanus, a general who was consul for the year 2 BC. Urgulanilla was named for his mother, Urgulania, a close friend of Livia.