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A pre-replication complex is a protein complex that forms at the origin of replication during the initiation step of DNA replication.
The following factors make up the complex:
- A helicase, which unwinds the DNA ahead of the fork (dnaA).
- A primase, which generates an RNA primer to be used in DNA replication (dnaG).
- A DNA holoenzyme, which is actually a complex of enzymes that performs the actual replication.
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