| Tenure
| Incumbent
| Affliation
| Notes
|
| French Somaliland
|
| 1957 to December 1958 | Mahamoud Harbi Farah, Vice President of the Government Council | PMP | fourlaba
|
| December 1958 to April 1959 | Hassan Gouled Aptidon, Vice President of the Government Council | PMP | Issa
|
| April 1959 to June 1960 | Ahmed Dini Ahmed, Vice President of the Government Council | LPAI | Afar
|
| June 1960 to 1966 | Ali Aref Bourhan, Vice President of the Government Council | UNI | Afar
|
| 1966 to 1967 | Abdallah Mohamed Kamil, Vice President of the Government Council | RDA | Afar
|
| French Territory of the Afars and Issas (FTAI)
|
| 7 July 1967 to 29 July 1976 | Ali Aref Bourhan, Presidents of the Government Council | UNI | Afar
|
| 29 July 1976 to 18 May 1977 | Abdallah Mohamed Kamil, President of the Government Council | RDA | Afar
|
| 18 May 1977 to 27 June 1977 | Hassan Gouled Aptidon, Prime Minister | RPP | Issa
|
| Republic of Djibouti (République Djibouti)
|
| جمهورية جيبوتي (Jumhūriyya Jibūt)
|
| 27 June 1977 to 12 July 1977 | Hassan Gouled Aptidon, Prime Minister | RPP | Issa
|
| 12 July 1977 to 5 February 1978 | Ahmed Dini Ahmed, Prime Minister | RPP | Afar
|
| 5 February 1978 to 2 October 1978 | Abdallah Mohamed Kamil, Prime Minister | RPP | Afar
|
| 2 October 1978 to 7 March 2001 | Barkat Gourad Hamadou, Prime Minister | RPP | Afar
|
| 7 March 2001 to present | Dileita Mohamed Dileita, Prime Minister | RPP |
|
