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The Shine-Dalgarno Sequence is the signal for initiation of protein synthesis. It consists primarily, but not exclusively, of an AUG codon and a rRNA-complementary sequence, the Shine Dalgarno sequence is
- AGGAGG
This sequence is usually located 4-7 nucleotides 5' of the initiator AUG of many mRNAs. The sequence is complementary to gaucaCCUCCUuaOH at the 3' end of 16S rRNA.
References
- Shine J, Dalgarno L. Determinant of cistron specificity in bacterial ribosomes. Nature. 1975 Mar 6;254(5495):34-38.
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