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Spondyloarthropathies are a group of related inflammatory joint disease associated with the MHC class I molecule HLA-B27. Subgroups (with increased HLA-B27 frequency) are:
- ankylosing spondylitis (AS, 90%),
- reactive arthritis (ReA)/Reiter's syndrome (RS, 80%),
- enteropathic arthritis associated with inflammatory bowel disease (IBD, 70%),
- Psoriatic arthritis (60%),
- isolated acute anterior uveitis (AAU, iritis or iridocyclitis, 50%), and
- undifferentiated SpA (USpA, 20-25%).
Whipple disease and Behçet disease may also be linked to HLA-B27.
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