In philosophy, substance means, approximately, that element of an object without which it would not exist. In the millennia-old Aristotelian tradition, as well as early modern traditions that follow it, substances are treated as having attributes and modes. For in-depth articles on the topic, see objecthood and substance theory.
Substance is sometimes used as a euphemism for harmful drugs.
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Example Usage of Substance
_num: Lol. Agree to an extent. RT @JamalShaikh: Party air kissing & conversations r like tweeting. Very brief, often of little Substance