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Sup35p is the Saccharomyces cerevisiae protein homologous to the translation termination factor eRF3.
Its function to terminate the translation process when the ribosome encounters a stop codon. Loss of function of Sup35p results in nonsense suppression, in which stop codons are ignored and proteins are abnormally synthesized with carboxyl terminal extensions.
Sup35p also forms the yeast prion [PSI+].
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