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Titu Cusi (1529 - 1571) was a son of Manco Inca Yupanqui, and became the Inca Ruler of Vilcabamba in 1558. He ruled until his death in 1571. During his rule at Vilcabamba, Francisco de Toledo wanted to negotiate with him. The negotiations were about Cusi leaving the fortress and accepting a Crown Pension. After negotiations escalated, around 1568, Cusi was baptised into the Catholic Church. His close companion Friar Diego Ortiz was blamed for killing Titu by poisoning him. Titu Cusi made Tupac Amaru a priest and custodian of Manco Inca's body in Vilcabamba. Tupac Amaru became the Inca Ruler after TituÂ’s death in 1571.
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