Panama's largest international air gateway is located at Tocumen International Airport (IATA airport code PTY) in Panama City.

Tocumen is a large facility and center of flights heading to and from the Caribbean, South America, North America and all of Central America. Also, one European city (Madrid) is served. Tocumen is the hub of Panama's international airline, Copa.

On July 2,2004, a Medevac flying from Quito, Ecuador to Washington, D.C. made a stopover at this airport and crashed during the subsequent take off, killing six persons on board and an airport worker.

Airlines serving Tocumen include:

• Aeroflot
• Aeroperlas
• American Airlines
• Avensa
• Avianca
• Continental Airlines
• Copa
• Cubana De Aviacion
• Delta Airlines
• Iberia
• Lacsa
• Lan Chile
• Lloyd Aereo Boliviano
• Mexicana
• Nica
• Taca

es:Aeropuerto Internacional Tocumen