The Endeavor was one of the twenty ships that participated in Jean-Luc Picard's blockading of the Romulan supply ships who provided the Duras family with weapons during the Klingon Civil War.
In 2367, the Endeavor fought in the cataclysmic Battle of Wolf 359 against the Borg where she was the sole surviving ship in the battle. (Its captain, Amasov, called the Borg "pure evil", as Captain Janeway quoted in the Star Trek: Voyager episode "Scorpion, Part I")
In 2368, the Endeavor was supposed to meet the USS Enterprise-D in the Cleon sector where Ktarian operatives would spread an addictive game in order to take control of Starfleet.
