Van Nuys is a district within the city of Los Angeles, California, United States.

Van Nuys is in the heart of the San Fernando Valley; the main thoroughfare, Van Nuys Boulevard, is noted for its car dealerships and the Government center (Erwin Street Mall) containing a branch of the Los Angeles County Superior Court, Van Nuys police station, the Van Nuys City Hall, and a branch of the Public Library.

Van Nuys used to be the home for a major manufacturing plant for Chevrolet. When the plant was dismantled the site was converted into a shopping mall called The Plant.

Like many central Valley neighborhoods, Van Nuys was formerly a white middle-class neighborhood as late as the 1970s but the demographics of the area have changed considerably due to white flight. It is now a predominantly Latino neighborhood and has been ravaged by urban decay, gangs, and a high crime rate.

Notable locations:

• Van Nuys Airport.
• Donald Tillman Japanese Gardens
• Sepulveda Dam