The Wappo were a group of Native Americans who lived in the Napa and Russian River areas of Northern California.

Their name is an Americanization of the Spanish term 'Guapo', 'brave', given them on account of their stubborn resistance to Spanish military aggression.

They lived by hunting and gathering, and lived in small groups without centralized political authority.

Alfred Kroeber estimated that there were 1,000 Wappo in 1770. The 1910 Census returned 73.