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Linkage - Dictionary Definition and Overview |
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Linkage : (noun)
1: an associative relation
2: (genetics) traits that tend to be inherited together as a
consequence of an association between their genes; all of
the genes of a given chromosome are linked (where one goes
they all go) [syn: gene linkage]
3: a mechanical system of rods or springs or pivots that
transmits power or motion
4: the act of linking things together
Based on WordNet 2.0
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Linkage : \Link"age\ (l[i^][ng]k"[asl]j; 48), n.
1. The act of linking; the state of being linked; also, a
system of links.
2. (Chem.) Manner of linking or of being linked; -- said of
the union of atoms or radicals in the molecule.
3. (Geom.) A system of straight lines or bars, fastened
together by joints, and having certain of their points
fixed in a plane. It is used to describe straight lines
and curves in the plane.
Based on Webster's Revised Unabridged Dictionary
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Linkage : Linkage: The tendency for genes and other genetic markers to be inherited together because of their location near one another on the same chromosome .
A protein .
The term "genetic marker" is broader. A genetic marker is simply a segment of DNA with an identifiable physical location on a chromosome whose inheritance can be followed. A genetic marker can
have a function and thus be a gene. Or a marker can be a section of DNA with no known function.
Because DNA segments that lie near each other on a chromosome tend to be inherited together, markers are often used as tools for tracking the inheritance pattern of a gene that has not yet been
identified but whose approximate location is known.
The statistical estimate of whether two loci are likely to lie near each other on a chromosome and are therefore likely to be inherited together is called a LOD score . A LOD score of 3 or more
is generally taken to indicate that the two loci are linked and are close to one another.
Based on Webster's Revised Unabridged Dictionary (1913)
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