|
Topoisomerase - Dictionary Definition and Overview |
|
Topoisomerase : Topoisomerase: A class of molecule coils up like a telephone cord, which shortens the molecule.) The topoisomerases act by transiently cutting one or both strands of the DNA.
Topoisomerase type I cuts one strand whereas topoisomerase type II cuts both strands of the DNA to relax the coil and extend the DNA molecule.
The regulation of DNA supercoiling is essential to DNA transcription and replication, when the DNA helix must unwind to permit the proper function of the enzymatic machinery involved in these
processes. Topoisomerases serve to maintain both the replication of DNA.
Aside from topoisomerases I and II, there are more discovered topoisomerases. Topoisomerase III may regulate recombination while topoisomerase IV regulates the process of segregating newly
replicated chromosomes from one another.
|
|
|
|
|
